For me, it depends on the sample and what sounds best. Most of time I sample my drums in mono but for some kicks and snares (depending on what source I'm liffing them from) I'll sample the drums in stereo to get a more full sound and capture the ambiance of what's going on behind them or maybe I'll sample a hot snare and then re-sample it through the ASR-10 with a just a little reverb to make it "shmack"!!! I always take into account what's going on behind the drums in the songs I want to sample.